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Combination data with diet suggest complementary mechanisms, and reviews highlight continued medicinal-chemistry work to tune potency, selectivity, and exposure for future translational studies

A randomized, double-blind, placebo-controlled trial in 88 patients with sepsis and elevated blood concentrations of lactate reported that intravenous thiamin (200 mg twice daily for seven days or until discharge from the hospital) did not decrease lactate concentrations at 24 hours post initiation of treatment the primary endpoint of the trial (104)

D.OrigaR.ZappuA.et al (2006)

No confirmed harm: To date, no clinical reports have indicated harm to babies born to pregnant women who previously used Botox

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However, early tBHQ research demonstrated that the addition of tBHQ increases NRF2-mediated transcription and confers neuroprotection from glutamate-induced oxidative damage (Shih et al., 2003